From Vision to Action

«To engage SILAB in socially committed action while confirming its scientific culture, fundamental values and humanism – it is for these reasons that I decided on this creation» Jean PAUFIQUE.

The aim of the SILAB - Jean PAUFIQUE Corporate Foundation is to provide active and constant support for Fundamental and applied Research dedicated to the diagnosis, prognosis and treatment of skin pathologies, particularly skin cancer.

Professors Philippe HUMBERT and Christophe BEDANE, opinion leaders in the domain of Dermatological Research, have joined the Governing Body of the Corporate Foundation. They make an essential contribution to the corporate approach based on shared values: a passion for Research and support for young talent.


2022 prize-winner: Anna LLEBARIA FABRIAS

Anna LLEBARIA FABRIAS Anna LLEBARIA FABRIAS was named the 15th prize-winner of the SILAB - Jean PAUFIQUE Corporate Foundation.
The project of Anna LLEBARIA FABRIAS is entitled “Influence of enzyme IL4I1 on the microbiota during melanoma development and on the response to an anti-PD1 antibody”. This work will be carried out in the Institut Cochin (INSERM U1016, CNRS UMR 8104, University of Paris-Cité) in Paris under the direction of Dr. Armelle PREVOST-BLONDEL (IL4I1 et melanoma) jointly with Dr. Benoit CHASSAING (Microbiota of mucus membranes and chronic inflammatory diseases). This project is intended to determine the influence of the bactericidal enzyme IL4I1 on the composition of the intestinal and cutaneous microbiota in a model of spontaneous metastatic melanoma in mice. Using in vivo and in vitro approaches, the group will investigate the contribution of bacteria in tumor development and resistance to immunotherapies, and will attempt to identify bacteria with antitumor activity. The results of this work could lead to proposing new strategies based on modulating the microbiota in order to boost the efficacy of anti-PD1 antibodies in patients suffering from cutaneous melanoma.